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Carbamazepine 10,11-epoxide

CAS No. 36507-30-9

Carbamazepine 10,11-epoxide( )

Catalog No. M28116 CAS No. 36507-30-9

Carbamazepine 10,11-epoxide is an active metabolite of the anticonvulsant carbamazepine.

Carbamazepine 10,11-epoxide is an active metabolite of the anticonvulsant carbamazepine.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Carbamazepine 10,11-epoxide
  • Note
    Research use only, not for human use.
  • Brief Description
    Carbamazepine 10,11-epoxide is an active metabolite of the anticonvulsant carbamazepine.
  • Description
    Carbamazepine 10,11-epoxide is an active metabolite of the anticonvulsant carbamazepine.It is formed from carbamazepine by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP2C8 in microsomes prepared from HepG2 cells expressing CYP3A4 or CYP2C8, respectively.Carbamazepine 10,11-epoxide has anticonvulsant activity against maximal electroshock-induced seizures in mice.2It has been found in wastewater effluent.
  • In Vitro
  • In Vivo
  • Synonyms
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    PDE4|PDE4B1|PDE4D7
  • Research Area
  • Indication

Chemical Information

  • CAS Number
    36507-30-9
  • Formula Weight
    252.273
  • Molecular Formula
    C15H12N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (495.50 mM)
  • SMILES
    NC(=O)N1c2ccccc2C2OC2c2ccccc12
  • Chemical Name

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Zheng-Qiang Zou, et al. Novel Phosphodiesterase 4 Inhibitor FCPR03 Alleviates Lipopolysaccharide-Induced Neuroinflammation by Regulation of the cAMP/PKA/CREB Signaling Pathway and NF- κ B Inhibition. J Pharmacol Exp Ther. 2017 Jul;362(1):67-77.
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